Dark matter (or, more accurately, transparent matter, which does not interact with the electromagnetic force) has been proposed to explain anomalies in the rotation curves of galaxies, the velocities of galaxies within galactic clusters, and the structure of the cosmic background radiation. Without dark matter (taking account only visible stars, gas, and dust) Newtonian gravitation produces incorrect predictions for these observations. (At these scales, the corrections of Einstein’s general relativity are insignificant.) But the gravitational accelerations at these scales are far below those which can be tested in the laboratory or measured in the solar system.
In 1983, Israeli physicist Mordehai Milgrom proposed a theory, Modified Newtonian Dynamics (MOND), in which at low accelerations the force of gravity departs from the inverse square law of Newton and approaches a linear relationship. This theory makes correct predictions of a variety of observations without invoking dark matter, and while it does not explain some other observations, MOND advocates argue that dark matter has difficulty with them as well.
In this interview astronomer Stacy McGaugh describes how his work with low surface brightness galaxies led him to doubt the plausibility of dark matter as an explanation for their rotation curves and, combined with experiments having ruled out a large number of candidates proposed for dark matter, investigate MOND as an alternative explanation for observations.